Fannie W Chen Selected Research

Lipidoses

9/2022	Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction.
1/2017	Normalization of Hepatic Homeostasis in the Npc1nmf164 Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat.
3/2009	Endosomal lipid accumulation in NPC1 leads to inhibition of PKC, hypophosphorylation of vimentin and Rab9 entrapment.
9/2005	NPC1 late endosomes contain elevated levels of non-esterified ('free') fatty acids and an abnormally glycosylated form of the NPC2 protein.

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Fannie W Chen Research Topics

Disease

4	Lipidoses 09/2022 - 09/2005
3	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 01/2017 - 09/2005
1	Body Weight (Weight, Body) 01/2017
1	Weight Loss (Weight Reduction) 01/2017
1	Disease Progression 01/2017
1	Lysosomal Storage Diseases (Lysosomal Storage Disease) 03/2009

Drug/Important Bio-Agent (IBA)

3	CholesterolIBA 07/2011 - 09/2005
2	LipidsIBA 01/2017 - 03/2009
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 09/2022
1	Proteins (Proteins, Gene)FDA Link 09/2022
1	Histone Deacetylase InhibitorsIBA 01/2017
1	Niemann-Pick C1 ProteinIBA 01/2017
1	Vorinostat FDA Link 01/2017
1	SphingolipidsIBA 07/2011
1	Histone Deacetylases (Histone Deacetylase)IBA 07/2011
1	GangliosidesIBA 03/2009
1	GlycosphingolipidsIBA 03/2009
1	Fatty Acids (Saturated Fatty Acids)IBA 03/2009
1	LDL Lipoproteins (beta Lipoproteins)IBA 09/2005
1	oxidized low density lipoproteinIBA 09/2005

Therapy/Procedure

1	Therapeutics 01/2017